Nature Communications (Jun 2021)
The long non-coding RNA βFaar regulates islet β-cell function and survival during obesity in mice
- Fangfang Zhang,
- Yue Yang,
- Xi Chen,
- Yue Liu,
- Qianxing Hu,
- Bin Huang,
- Yuhong Liu,
- Yi Pan,
- Yanfeng Zhang,
- Dechen Liu,
- Rui Liang,
- Guoqing Li,
- Qiong Wei,
- Ling Li,
- Liang Jin
Affiliations
- Fangfang Zhang
- State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, School of Life Science and Technology, China Pharmaceutical University
- Yue Yang
- State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, School of Life Science and Technology, China Pharmaceutical University
- Xi Chen
- State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, School of Life Science and Technology, China Pharmaceutical University
- Yue Liu
- State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, School of Life Science and Technology, China Pharmaceutical University
- Qianxing Hu
- State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, School of Life Science and Technology, China Pharmaceutical University
- Bin Huang
- State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, School of Life Science and Technology, China Pharmaceutical University
- Yuhong Liu
- State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, School of Life Science and Technology, China Pharmaceutical University
- Yi Pan
- State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, School of Life Science and Technology, China Pharmaceutical University
- Yanfeng Zhang
- State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, School of Life Science and Technology, China Pharmaceutical University
- Dechen Liu
- Department of Endocrinology, Zhongda Hospital, School of Medicine, Southeast University
- Rui Liang
- Organ Transplant Center, Tianjin First Central Hospital, Nankai University
- Guoqing Li
- Department of Endocrinology, Zhongda Hospital, School of Medicine, Southeast University
- Qiong Wei
- Department of Endocrinology, Zhongda Hospital, School of Medicine, Southeast University
- Ling Li
- Department of Endocrinology, Zhongda Hospital, School of Medicine, Southeast University
- Liang Jin
- State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, School of Life Science and Technology, China Pharmaceutical University
- DOI
- https://doi.org/10.1038/s41467-021-24302-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Beta-cell function is often impaired in obesity through incompletely understood mechanisms. Here the authors show that the long noncoding RNA βFaar is reduced by diet-induced obesity in mice, which leads to impaired beta-cell function via miR-138-5p and survival via TRAF3 Interacting Protein 2.
