Communications Medicine (Jan 2022)

Functional brain activity constrained by structural connectivity reveals cohort-specific features for serum neurofilament light chain

  • Saurabh Sihag,
  • Sébastien Naze,
  • Foad Taghdiri,
  • Melisa Gumus,
  • Charles Tator,
  • Robin Green,
  • Brenda Colella,
  • Kaj Blennow,
  • Henrik Zetterberg,
  • Luis Garcia Dominguez,
  • Richard Wennberg,
  • David J. Mikulis,
  • Maria C. Tartaglia,
  • James R. Kozloski

DOI
https://doi.org/10.1038/s43856-021-00065-5
Journal volume & issue
Vol. 2, no. 1
pp. 1 – 14

Abstract

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Sihag et al. analyse brain imaging data, circulating neurofilament light chain levels and personality scores in a cohort of former athletes with a history of concussions. The authors use graph signal processing to identify brain structural and connectivity features associated with neurofilament levels and with aggressive behaviour.