Communications Biology (Jul 2021)

Butyrophilin-like 2 regulates site-specific adaptations of intestinal γδ intraepithelial lymphocytes

  • Casandra Panea,
  • Ruoyu Zhang,
  • Jeffrey VanValkenburgh,
  • Min Ni,
  • Christina Adler,
  • Yi Wei,
  • Francisca Ochoa,
  • Jennifer Schmahl,
  • Yajun Tang,
  • Chia-Jen Siao,
  • William Poueymirou,
  • Jennifer Espert,
  • Wei Keat Lim,
  • Gurinder S. Atwal,
  • Andrew J. Murphy,
  • Matthew A. Sleeman,
  • Zaruhi Hovhannisyan,
  • Sokol Haxhinasto

DOI
https://doi.org/10.1038/s42003-021-02438-x
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 16

Abstract

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Panea et al showed that epithelia-specific butyrophilinlike 2 (Btnl2) suppressed homeostatic proliferation of γδ intraepithelial lymphocytes (IELs) preferentially in the ileum and used high throughput transcriptomic characterization of Btnl2-deficient γδ IELs to demonstrate that Btnl2 impacts γδ TCR specificities and repertoire diversity of ileal γδ IELs. In addition, they showed that Btnl2-deficient mice exhibited increased inflammation and delayed mucosal repair in the colon, suggesting that it plays a key immunological function in intestinal diseases.