Serous adenocarcinoma of endometrium coexistence with atypical polypoid adenomyoma in a postmenopausal woman: A rare case

Abstract

This work describes a rare case of serous carcinoma coexistence with atypical polypoid adenomyoma (APA). A 55-year-old postmenopausal woman presented with intermittent vaginal bleeding for 1 year. Her Pap test exhibited atypical glandular cell and endometrial biopsy showed serous carcinoma. She underwent a staging surgery, and the histopathology revealed serous carcinoma with p53 mutation and coexistence with APA staged as FIGO Stage Ia, Grade 1. The patient recovered well postoperatively. APA lesion is generally benign, but it may progress in rare cases to adenocarcinoma, usually endometrioid type. This is the first case report regarding serous carcinoma coexistence with APA. Therefore, the patient with APA should always be closely followed up. Nevertheless, further study is stipulated to better understand the clinicopathological features of serous adenocarcinoma coexisting with APA.

Keywords

• Atypical polypoid adenomyoma
• endometrium
• menopause
• serous carcinoma