Nature Communications (Jan 2021)

Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients

  • Yongliang Zhang,
  • Yu Yao,
  • Yaping Xu,
  • Lifeng Li,
  • Yan Gong,
  • Kai Zhang,
  • Meng Zhang,
  • Yanfang Guan,
  • Lianpeng Chang,
  • Xuefeng Xia,
  • Lin Li,
  • Shuqin Jia,
  • Qiang Zeng

DOI
https://doi.org/10.1038/s41467-020-20162-8
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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The detection of aberrations in circulating tumour DNA represents a non-invasive method to survey the oncogenes and tumour suppressors that are modified within a patient’s cancer. Here, the authors analysed more than 10,000 patients using a targeted sequencing panel and report on the frequencies of the mutations that they found.