Structural basis for gating mechanism of the human sodium-potassium pump

Phong T. Nguyen; Christine Deisl; Michael Fine; Trevor S. Tippetts; Emiko Uchikawa; Xiao-chen Bai; Beth Levine

doi:10.1038/s41467-022-32990-x

Nature Communications (Sep 2022)

Structural basis for gating mechanism of the human sodium-potassium pump

Phong T. Nguyen,
Christine Deisl,
Michael Fine,
Trevor S. Tippetts,
Emiko Uchikawa,
Xiao-chen Bai,
Beth Levine

Affiliations

Phong T. Nguyen: Howard Hughes Medical Institute and Department of Internal Medicine, University of Texas Southwestern Medical Center
Christine Deisl: Department of Physiology, University of Texas Southwestern Medical Center
Michael Fine: Department of Physiology, University of Texas Southwestern Medical Center
Trevor S. Tippetts: Children’s Research Institute, University of Texas Southwestern Medical Center
Emiko Uchikawa: Department of Biophysics, University of Texas Southwestern Medical Center
Xiao-chen Bai: Department of Biophysics, University of Texas Southwestern Medical Center
Beth Levine: Howard Hughes Medical Institute and Department of Internal Medicine, University of Texas Southwestern Medical Center

DOI: https://doi.org/10.1038/s41467-022-32990-x
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

Read online

Through cryo-EM analysis, here authors reveal conformational rearrangements that are critical for the gating mechanism of the human alpha3 Na+/K+−ATPase

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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