A TAD boundary is preserved upon deletion of the CTCF-rich Firre locus

A. Rasim Barutcu; Philipp G. Maass; Jordan P. Lewandowski; Catherine L. Weiner; John L. Rinn

doi:10.1038/s41467-018-03614-0

Nature Communications (Apr 2018)

A TAD boundary is preserved upon deletion of the CTCF-rich Firre locus

A. Rasim Barutcu,
Philipp G. Maass,
Jordan P. Lewandowski,
Catherine L. Weiner,
John L. Rinn

Affiliations

A. Rasim Barutcu: Department of Stem Cell and Regenerative Biology, Harvard University
Philipp G. Maass: Department of Stem Cell and Regenerative Biology, Harvard University
Jordan P. Lewandowski: Department of Stem Cell and Regenerative Biology, Harvard University
Catherine L. Weiner: Department of Stem Cell and Regenerative Biology, Harvard University
John L. Rinn: Department of Stem Cell and Regenerative Biology, Harvard University

DOI: https://doi.org/10.1038/s41467-018-03614-0
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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Although CTCF binding has been implicated in the formation of topologically associated domains (TADs) the mechanisms folding the genome into TADs are not fully understood. Here the authors investigate the TAD boundary on lncRNA locus Firre, which has ~ 15 CTCF binding sites, and its organization.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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