The relationship between the second trimester screening biochemical markers and complications and anomalies in pregnant women.

Abstract

Aim: We aimed to investigate the relationship between AFP, uE3, beta hCG, maternal age and Down syndrome, NTD and trisomy 18 risk levels and prenatal maternal or fetal complications, postnatal chromosomal anomalies, emergence of high or low birthweight births, in pregnant with triple test. Method: The pregnancy complications occurred during pregnancy of 82 patients, whose triple screens were done in our clinic during the years of 2010-2012, were investigated retrospectively, and post pregnant chromosomal abnormalities, neural tube defects (NTDs), high and low birth weight cases were found out by calling the patients and by searching their files. Multiple of median (MoM) values were calculated by measuring AFP, uE3, and beta hCG levels with chemiluminescent method via Beckman Coulter UniCelDxI 800 device. Results: The average age of the women in the study group was 27.7. The risk has been identified, for Down syndrome in 8 patients, for NTD in 10 patients, for trisomy 18 in 3 patients, over 1/250. The number of patients with preeclampsia was 2; gestational diabetes mellitus (DM) was 8 during pregnancy. While the number of babies born with low birthweight was 13, high birthweight infants’ number was 11. Conclusion: In order to determine false postivities more properly, further studies with a higher number of cases are recommended. Advanced clinical trials are recommended for increasing the safety of pregnancy screening tests.

Keywords

• üçlü tarama testi
• kromozomal anomaliler
• triple screening test
• chromosomal abnormalities