Plasma hepatic enzymes as biopredictors of type, metastasis, and prognostication of hematological malignancies

Abstract

Background and Aim: The present study evaluated the levels of some hepatic enzymes in the plasma of Nigerians affected with hematological malignancies, to determine if these enzymes could be established as predictors of possible metastasis to the liver, the degree of severity of the disease or prognostication of hematological malignancies. Materials and Methods: Twenty-seven consented subjects with multiple myeloma (n = 4), non-Hodgkins lymphoma (n = 5), Hodgkins lymphoma (n = 5), chronic myeloid leukemia (n = 6), and chronic lymphoid leukemia (n = 6) as well as control subjects (n = 7) were recruited having gotten the ethical approval from the authorities of the teaching hospitals used for the study. Evaluations of activities of enzymes (acid and alkaline phosphatases, alanine and aspartate transaminases, lactate, and glucose-6-phosphate dehydrogenases) were carried out in the samples collected. Statistical analysis was performed using SPSS version 20 software. Results: Statistically significant levels of the enzymes were found in chronic hematological malignancies such as chronic myeloid leukemia and chronic lymphoid leukemia. Conclusion: Evaluating the plasma levels of hepatic enzymes in Nigerians affected with hematological malignancies could assist in predicting possible metastasis to the liver, type or the degree of severity of the disease, or prognostication of hematological malignancies affected.

Keywords

• Hepatic enzymes
• biopredictors
• metastasis
• prognostication
• hematological malignancies