Triiodothyronine and Protein Malnutrition Could Influence Pulse Wave Velocity in Pre-Dialysis Chronic Kidney Disease Patients
Crina Claudia Rusu,
Ina Kacso,
Diana Moldovan,
Alina Potra,
Dacian Tirinescu,
Maria Ticala,
Ancuta M. Rotar,
Remus Orasan,
Cristian Budurea,
Andrada Barar,
Florin Anton,
Ana Valea,
Cosmina Ioana Bondor,
Madalina Ticolea
Affiliations
Crina Claudia Rusu
Department of Nephrology, University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj, 8 Victor Babeș Street, 400012 Cluj-Napoca, Romania
Ina Kacso
Department of Nephrology, University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj, 8 Victor Babeș Street, 400012 Cluj-Napoca, Romania
Diana Moldovan
Department of Nephrology, University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj, 8 Victor Babeș Street, 400012 Cluj-Napoca, Romania
Alina Potra
Department of Nephrology, University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj, 8 Victor Babeș Street, 400012 Cluj-Napoca, Romania
Dacian Tirinescu
Department of Nephrology, University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj, 8 Victor Babeș Street, 400012 Cluj-Napoca, Romania
Maria Ticala
Department of Nephrology, University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj, 8 Victor Babeș Street, 400012 Cluj-Napoca, Romania
Ancuta M. Rotar
Department of Food Science, Faculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Calea Manastur 3-5, 400372 Cluj-Napoca, Romania
Remus Orasan
Nefromed Dialysis Center, 40 Ana Aslan Street, 400528 Cluj-Napoca, Romania
Cristian Budurea
Nefromed Dialysis Center, 40 Ana Aslan Street, 400528 Cluj-Napoca, Romania
Andrada Barar
Department of Nephrology, County Emergency Clinical Hospital Cluj, 3-5 Clinicilor Street, 400006 Cluj-Napoca, Romania
Florin Anton
Department of Cardiology, University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj, 8 Victor Babeș Street, 400012 Cluj-Napoca, Romania
Ana Valea
Department of Endocrinology, University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj, 8 Victor Babeș Street, 400012 Cluj-Napoca, Romania
Cosmina Ioana Bondor
Department of Medical Informatics and Biostatistics, University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj, 6 Pasteur Street, 400349 Cluj-Napoca, Romania
Madalina Ticolea
Department of Nephrology, County Emergency Clinical Hospital Cluj, 3-5 Clinicilor Street, 400006 Cluj-Napoca, Romania
Cardiovascular diseases (CVD) are the first cause of chronic kidney disease (CKD) mortality. For personalized improved medicine, detecting correctable markers of CVD can be considered a priority. The aim of this study was the evaluation of the impact of nutritional, hormonal and inflammatory markers on brachial-ankle Pulse Wave Velocity (PWV) in pre-dialysis CKD patients. A cross-sectional observational study was conducted on 68 pre-dialysis CKD patients (median age of 69 years, 41.2% with diabetes mellitus, 52.9% male). Laboratory data were collected, including levels of prolactin, triiodothyronine, TGF α, IL-6, and IL-1β. The high values of brachial-ankle PWV were associated with reduced muscle mass (p = 0.001, r = −0.44), low levels of total cholesterol (p = 0.04, r = −0.26), triglycerides (p = 0.03, r = −0.31), triiodothyronine (p = 0.04, r = −0.24), and prolactin (p = 0.02, r = −0.27). High PWV was associated with advanced age (p p = 0.018), low levels of triiodothyronine (p = 0.002), and triglycerides (p = 0.049) were significant predictors of PWV, but age (p < 0.001) remained an important factor. In conclusion, reduced triiodothyronine together with markers of malnutrition and age were associated with PWV in pre-dialysis CKD patients.