Nature Communications (Sep 2017)

A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival

  • Elias Bou Samra,
  • Géraldine Buhagiar-Labarchède,
  • Christelle Machon,
  • Jérôme Guitton,
  • Rosine Onclercq-Delic,
  • Michael R. Green,
  • Olivier Alibert,
  • Claude Gazin,
  • Xavier Veaute,
  • Mounira Amor-Guéret

DOI
https://doi.org/10.1038/s41467-017-00633-1
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 14

Abstract

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Cytidine deaminase (CDA) deficiency leads to genome instability. Here the authors find a synthetic lethal interaction between CDA and the microtubule-associated protein Tau deficiencies, and report that Tau depletion affects rRNA synthesis, ribonucleotide pool balance, and rDNA stability.