Nature Communications (Sep 2017)
A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival
Abstract
Cytidine deaminase (CDA) deficiency leads to genome instability. Here the authors find a synthetic lethal interaction between CDA and the microtubule-associated protein Tau deficiencies, and report that Tau depletion affects rRNA synthesis, ribonucleotide pool balance, and rDNA stability.