MOLECULAR GENETICS STUDY FUNCTIONING POLYMORPHIC GENE VARIANTS CYTOKINE NETWORK AND BIOTRANSFORMATION OF XENOBIOTICS FOR CANCER

Abstract

The interrelation of polymorphic loci genes cytokine profile with indicators spontaneous cytokine production oxists. Combination of genotypes identified family interleukin -1, and having functional significance adaptive " mutant " alleles (* E2/* II /* C) in the genes of the interleukin -1 was significantly more frequent in cancer patients " risk" alleles of the tumor suppressor gene TP53. It’s revealed that the cancer patients in the combined genotype " mutant " alleles in the gene not only NQO1, but also genes of the interleukin -1 wich where studied.

Keywords

• цитокины
• онкосупрессор
• сывороточные показатели цитокинов
• генетическое типирование