Nature Communications (Feb 2022)
Physiological synaptic activity and recognition memory require astroglial glutamine
- Giselle Cheung,
- Danijela Bataveljic,
- Josien Visser,
- Naresh Kumar,
- Julien Moulard,
- Glenn Dallérac,
- Daria Mozheiko,
- Astrid Rollenhagen,
- Pascal Ezan,
- Cédric Mongin,
- Oana Chever,
- Alexis-Pierre Bemelmans,
- Joachim Lübke,
- Isabelle Leray,
- Nathalie Rouach
Affiliations
- Giselle Cheung
- Neuroglial Interactions in Cerebral Physiology and Pathologies, Center for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS, INSERM, Labex Memolife, Université PSL
- Danijela Bataveljic
- Neuroglial Interactions in Cerebral Physiology and Pathologies, Center for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS, INSERM, Labex Memolife, Université PSL
- Josien Visser
- Neuroglial Interactions in Cerebral Physiology and Pathologies, Center for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS, INSERM, Labex Memolife, Université PSL
- Naresh Kumar
- Université Paris Saclay, ENS Paris-Saclay, CNRS, PPSM
- Julien Moulard
- Neuroglial Interactions in Cerebral Physiology and Pathologies, Center for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS, INSERM, Labex Memolife, Université PSL
- Glenn Dallérac
- Neuroglial Interactions in Cerebral Physiology and Pathologies, Center for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS, INSERM, Labex Memolife, Université PSL
- Daria Mozheiko
- Neuroglial Interactions in Cerebral Physiology and Pathologies, Center for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS, INSERM, Labex Memolife, Université PSL
- Astrid Rollenhagen
- Institute for Neuroscience and Medicine INM-10, Research Center Jülich
- Pascal Ezan
- Neuroglial Interactions in Cerebral Physiology and Pathologies, Center for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS, INSERM, Labex Memolife, Université PSL
- Cédric Mongin
- Université Paris Saclay, ENS Paris-Saclay, CNRS, PPSM
- Oana Chever
- Neuroglial Interactions in Cerebral Physiology and Pathologies, Center for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS, INSERM, Labex Memolife, Université PSL
- Alexis-Pierre Bemelmans
- Commissariat à l’Energie Atomique et aux Energies Alternatives, Département de la Recherche Fondamentale, Institut de biologie François Jacob, Molecular Imaging Research Center and CNRS UMR9199, Université Paris-Sud, Neurodegenerative Diseases Laboratory
- Joachim Lübke
- Institute for Neuroscience and Medicine INM-10, Research Center Jülich
- Isabelle Leray
- Université Paris Saclay, ENS Paris-Saclay, CNRS, PPSM
- Nathalie Rouach
- Neuroglial Interactions in Cerebral Physiology and Pathologies, Center for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS, INSERM, Labex Memolife, Université PSL
- DOI
- https://doi.org/10.1038/s41467-022-28331-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
The authors present a fluorescent probe that tracks glutamine in live cells. They demonstrate the capabilities of the probe by providing direct visual evidence of an activity-dependent glutamine supply from astroglial networks to presynaptic structures under physiological conditions.
