Continuous Chemistry in Microreaction Systems for Practical Use

Abstract

Handling manufacturing processes in microstructured continuous systems offers a variety of benefits to chemical as well as process performance. In this report, representative examples are given for profits in general process development, high exothermic/hazardous reactions, handling of products that are unstable under reaction conditions and product profile improvement. Specific focus was aimed at reasonable timeframes for 0.5–1 kg campaigns by using commercially available microreaction technology. After analyzing the individual contributions of flow technology, we assembled a competitive minimal microreaction system comprising all essential parts for running effective continuous chemistry.

Keywords

• Continuous chemistry
• Kilogram synthesis
• Microreaction technology
• Process intensification
• Scale-up