Right ventricular dyssynchrony: from load-independent right ventricular function to wall stress in severe pulmonary arterial hypertension

Manuel J. Richter; Roberto Badagliacca; Jun Wan; Rebecca Vanderpool; Antonia Dalmer; Hossein A. Ghofrani; Sebastian Harth; Werner Seeger; Henning Gall; Robert Naeije; Khodr Tello

doi:10.1177/2045894020925759

Pulmonary Circulation (May 2020)

Right ventricular dyssynchrony: from load-independent right ventricular function to wall stress in severe pulmonary arterial hypertension

Manuel J. Richter,
Roberto Badagliacca,
Jun Wan,
Rebecca Vanderpool,
Antonia Dalmer,
Hossein A. Ghofrani,
Sebastian Harth,
Werner Seeger,
Henning Gall,
Robert Naeije,
Khodr Tello

Affiliations

Manuel J. Richter: Department of Internal Medicine, Justus-Liebig-University Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Giessen, Germany
Roberto Badagliacca: Department of Cardiovascular and Respiratory Science, Sapienza University of Rome, Rome, Italy
Jun Wan: Department of Pulmonary and Critical Care Medicine, National Pulmonary Embolism & Pulmonary Vascular Diseases Research Group, National Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing, China
Rebecca Vanderpool: Division of Translational and Regenerative Medicine, University of Arizona, Tucson, Arizona
Antonia Dalmer: Department of Internal Medicine, Justus-Liebig-University Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Giessen, Germany
Hossein A. Ghofrani: Department of Medicine, Imperial College London, London, UK
Sebastian Harth: Department of Radiology, Justus-Liebig-University Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Giessen, Germany
Werner Seeger: Department of Internal Medicine, Justus-Liebig-University Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Giessen, Germany
Henning Gall: Department of Internal Medicine, Justus-Liebig-University Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Giessen, Germany
Robert Naeije: Department of Cardiology, Erasme University Hospital, Brussels, Belgium
Khodr Tello: Department of Internal Medicine, Justus-Liebig-University Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Giessen, Germany

DOI: https://doi.org/10.1177/2045894020925759
Journal volume & issue: Vol. 10

Abstract

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Right ventricular (RV) dyssynchrony has been related to outcome in pulmonary arterial hypertension. Prospectively, we performed echocardiography with measurement of right ventricular dyssynchrony and pressure–volume loop catheterization in 27 pulmonary arterial hypertension patients. Afterload and diastolic function emerged as determinates of wall stress, which results in dyssynchrony.

Published in Pulmonary Circulation

ISSN: 2045-8940 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system; Medicine: Internal medicine: Specialties of internal medicine: Diseases of the respiratory system
Website: https://onlinelibrary.wiley.com/journal/20458940

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