Nature Communications (Nov 2022)
RNA-controlled nucleocytoplasmic shuttling of mRNA decay factors regulates mRNA synthesis and a novel mRNA decay pathway
- Shiladitya Chattopadhyay,
- Jose Garcia-Martinez,
- Gal Haimovich,
- Jonathan Fischer,
- Aya Khwaja,
- Oren Barkai,
- Silvia Gabriela Chuartzman,
- Maya Schuldiner,
- Ron Elran,
- Miriam I. Rosenberg,
- Shira Urim,
- Shubham Deshmukh,
- Katherine E. Bohnsack,
- Markus T. Bohnsack,
- Jose E. Perez-Ortin,
- Mordechai Choder
Affiliations
- Shiladitya Chattopadhyay
- Department of Molecular Microbiology, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology
- Jose Garcia-Martinez
- Instituto de Biotecnología y Biomedicina (Biotecmed), Universitat de València; Burjassot
- Gal Haimovich
- Department of Molecular Microbiology, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology
- Jonathan Fischer
- Department of Biostatistics, University of Florida
- Aya Khwaja
- Department of Molecular Microbiology, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology
- Oren Barkai
- Department of Molecular Microbiology, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology
- Silvia Gabriela Chuartzman
- Department of Molecular Genetics, Weizmann Institute of Science
- Maya Schuldiner
- Department of Molecular Genetics, Weizmann Institute of Science
- Ron Elran
- Department of Molecular Microbiology, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology
- Miriam I. Rosenberg
- Department of Molecular Microbiology, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology
- Shira Urim
- Department of Molecular Microbiology, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology
- Shubham Deshmukh
- Department of Molecular Microbiology, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology
- Katherine E. Bohnsack
- Institute for Molecular Biology, University Medical Center Göttingen Georg-August-University
- Markus T. Bohnsack
- Institute for Molecular Biology, University Medical Center Göttingen Georg-August-University
- Jose E. Perez-Ortin
- Instituto de Biotecnología y Biomedicina (Biotecmed), Universitat de València; Burjassot
- Mordechai Choder
- Department of Molecular Microbiology, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology
- DOI
- https://doi.org/10.1038/s41467-022-34417-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Nucleocytoplasmic shuttling of several yeast mRNA decay factors regulates transcription and initiates a novel mRNA decay pathway; shuttling is controlled by the decaying RNA and is critical for coping with environmental changes.
