Nature Communications (Jan 2021)

A logical network-based drug-screening platform for Alzheimer’s disease representing pathological features of human brain organoids

  • Jong-Chan Park,
  • So-Yeong Jang,
  • Dongjoon Lee,
  • Jeongha Lee,
  • Uiryong Kang,
  • Hongjun Chang,
  • Haeng Jun Kim,
  • Sun-Ho Han,
  • Jinsoo Seo,
  • Murim Choi,
  • Dong Young Lee,
  • Min Soo Byun,
  • Dahyun Yi,
  • Kwang-Hyun Cho,
  • Inhee Mook-Jung

DOI
https://doi.org/10.1038/s41467-020-20440-5
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 13

Abstract

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Developing effective drugs for Alzheimer’s disease (AD), the most common cause of dementia, has been difficult because of complicated pathogenesis. Here, the authors report an efficient network-based drug-screening platform developed by integrating mathematical modeling and the pathological features of human cerebral organoids.