Nature Communications (Oct 2018)

Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture

  • Joel I. Perez-Perri,
  • Birgit Rogell,
  • Thomas Schwarzl,
  • Frank Stein,
  • Yang Zhou,
  • Mandy Rettel,
  • Annika Brosig,
  • Matthias W. Hentze

DOI
https://doi.org/10.1038/s41467-018-06557-8
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

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RNA interactome capture allows the detailed investigation of RNA-bound proteomes. Here the authors describe enhanced RNA-interactome capture using LNA-modified probes for increased sensitivity and specificity.