Hyaluronic acid-modified and verteporfin-loaded polylactic acid nanogels promote scarless wound healing by accelerating wound re-epithelialization and controlling scar formation

Kun Chen; Yuanhu Liu; Xiaohui Liu; Yongli Guo; Jing Liu; Jiaojiao Ding; Zheng Zhang; Xin Ni; Yunsheng Chen

doi:10.1186/s12951-023-02014-x

Journal of Nanobiotechnology (Jul 2023)

Hyaluronic acid-modified and verteporfin-loaded polylactic acid nanogels promote scarless wound healing by accelerating wound re-epithelialization and controlling scar formation

Kun Chen,
Yuanhu Liu,
Xiaohui Liu,
Yongli Guo,
Jing Liu,
Jiaojiao Ding,
Zheng Zhang,
Xin Ni,
Yunsheng Chen

Affiliations

Kun Chen: Department of Burn and Plastic Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health
Yuanhu Liu: Department of Otolaryngology, Head and Neck Surgery, Beijing Children’ s Hospital, Capital Medical University, National Center for Children’ s Health
Xiaohui Liu: Department of Otolaryngology, Head and Neck Surgery, Beijing Children’ s Hospital, Capital Medical University, National Center for Children’ s Health
Yongli Guo: Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, MOE Key Laboratory of Major Diseases in Children, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health
Jing Liu: Department of Burn and Plastic Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health
Jiaojiao Ding: Department of Otolaryngology, Head and Neck Surgery, Beijing Children’ s Hospital, Capital Medical University, National Center for Children’ s Health
Zheng Zhang: Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University
Xin Ni: Department of Otolaryngology, Head and Neck Surgery, Beijing Children’ s Hospital, Capital Medical University, National Center for Children’ s Health
Yunsheng Chen: Department of Burn, Shanghai Burn Institute, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine

DOI: https://doi.org/10.1186/s12951-023-02014-x
Journal volume & issue: Vol. 21, no. 1
pp. 1 – 10

Abstract

Read online

Abstract Wound healing is a common occurrence. However, delayed healing and aberrant scarring result in pathological wound healing. Accordingly, a scarless wound healing remains a significant clinical challenge. In this study, we constructed hyaluronic acid (HA)-modified and verteporfin (VP)-loaded polylactic acid (PLA) nanogels (HA/VP-PLA) to promote scarless wound healing by accelerating wound re-epithelialization and controlling scar formation. Owing to the unique structure of HA incorporating and coating in VP-loaded PLA nanoparticles, HA/VP-PLA could be topically applied on wound to achieve targeted delivery to fibroblasts. Then, HA/VP-PLA released HA and lactic acid (LA) to stimulate the proliferation and migration of fibroblasts, as well as VP to inhibit Yes-associated protein (YAP) expression and nuclear localization to suppress fibrosis. In vitro (skin fibroblasts) and in vivo (rat and rabbit models) experiments strongly suggested that HA/VP-PLA promoted scarless wound healing by accelerating wound re-epithelialization and controlling scar formation. Therefore, our work provides a feasible strategy for scarless wound healing, and the sophisticated HA/VP-PLA exhibit a great potential for clinical applications.

Published in Journal of Nanobiotechnology

ISSN: 1477-3155 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Technology: Chemical technology: Biotechnology; Medicine: Medicine (General): Medical technology
Website: https://jnanobiotechnology.biomedcentral.com/

About the journal

Abstract

Keywords