Nature Communications (Oct 2019)
Identification and characterization of Cardiac Glycosides as senolytic compounds
- Francisco Triana-Martínez,
- Pilar Picallos-Rabina,
- Sabela Da Silva-Álvarez,
- Federico Pietrocola,
- Susana Llanos,
- Verónica Rodilla,
- Enrica Soprano,
- Pablo Pedrosa,
- Alba Ferreirós,
- Marta Barradas,
- Fernanda Hernández-González,
- Marta Lalinde,
- Neus Prats,
- Cristina Bernadó,
- Patricia González,
- María Gómez,
- Maria P. Ikonomopoulou,
- Pablo J. Fernández-Marcos,
- Tomás García-Caballero,
- Pablo del Pino,
- Joaquín Arribas,
- Anxo Vidal,
- Miguel González-Barcia,
- Manuel Serrano,
- María I. Loza,
- Eduardo Domínguez,
- Manuel Collado
Affiliations
- Francisco Triana-Martínez
- Laboratory of Stem Cells in Cancer and Aging, Health Research Institute of Santiago de Compostela (IDIS), Xerencia de Xestión Integrada de Santiago (XXIS/SERGAS)
- Pilar Picallos-Rabina
- Laboratory of Stem Cells in Cancer and Aging, Health Research Institute of Santiago de Compostela (IDIS), Xerencia de Xestión Integrada de Santiago (XXIS/SERGAS)
- Sabela Da Silva-Álvarez
- Laboratory of Stem Cells in Cancer and Aging, Health Research Institute of Santiago de Compostela (IDIS), Xerencia de Xestión Integrada de Santiago (XXIS/SERGAS)
- Federico Pietrocola
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST)
- Susana Llanos
- DNA Replication Group, Spanish National Cancer Research Centre (CNIO)
- Verónica Rodilla
- Preclinical Research Program, Vall d´Hebron Institute of Oncology (VHIO) and CIBERONC
- Enrica Soprano
- Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS) and Departamento de Física de Partículas, Universidade de Santiago de Compostela
- Pablo Pedrosa
- Laboratory of Stem Cells in Cancer and Aging, Health Research Institute of Santiago de Compostela (IDIS), Xerencia de Xestión Integrada de Santiago (XXIS/SERGAS)
- Alba Ferreirós
- Laboratory of Stem Cells in Cancer and Aging, Health Research Institute of Santiago de Compostela (IDIS), Xerencia de Xestión Integrada de Santiago (XXIS/SERGAS)
- Marta Barradas
- Metabolic Syndrome Group, Madrid Institute for Advanced Studies (IMDEA) in Food, CEI UAM+CSIC
- Fernanda Hernández-González
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST)
- Marta Lalinde
- Preclinical Research Program, Vall d´Hebron Institute of Oncology (VHIO) and CIBERONC
- Neus Prats
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST)
- Cristina Bernadó
- Preclinical Research Program, Vall d´Hebron Institute of Oncology (VHIO) and CIBERONC
- Patricia González
- Histopathology Unit, Spanish National Cancer Research Centre (CNIO)
- María Gómez
- Histopathology Unit, Spanish National Cancer Research Centre (CNIO)
- Maria P. Ikonomopoulou
- Translational Venomics Group, Madrid Institute for Advanced Studies (IMDEA) in Food, CEI UAM+CSIC
- Pablo J. Fernández-Marcos
- Metabolic Syndrome Group, Madrid Institute for Advanced Studies (IMDEA) in Food, CEI UAM+CSIC
- Tomás García-Caballero
- Departamento de Ciencias Morfológicas, Facultad de Medicina. USC. Xerencia de Xestión Integrada de Santiago (XXIS/SERGAS)
- Pablo del Pino
- Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS) and Departamento de Física de Partículas, Universidade de Santiago de Compostela
- Joaquín Arribas
- Preclinical Research Program, Vall d´Hebron Institute of Oncology (VHIO) and CIBERONC
- Anxo Vidal
- CiCLOn, Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidade de Santiago de Compostela, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)
- Miguel González-Barcia
- Servicio de Farmacia, Xerencia de Xestión Integrada de Santiago (XXIS/SERGAS)
- Manuel Serrano
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST)
- María I. Loza
- BioFarma, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, Health Research Institute of Santiago de Compostela (IDIS)
- Eduardo Domínguez
- BioFarma, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, Health Research Institute of Santiago de Compostela (IDIS)
- Manuel Collado
- Laboratory of Stem Cells in Cancer and Aging, Health Research Institute of Santiago de Compostela (IDIS), Xerencia de Xestión Integrada de Santiago (XXIS/SERGAS)
- DOI
- https://doi.org/10.1038/s41467-019-12888-x
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
Senolytic compounds have the ability to eliminate senescent cells from tissues and have been shown to be beneficial in various animal models of age-related diseases. Here the authors show that cardiac glycosides commonly used for heart diseases have senolytic properties in humanized mouse models of tumorigenesis and lung fibrosis.
