Nature Communications (Sep 2017)

The interdependent network of gene regulation and metabolism is robust where it needs to be

  • David F. Klosik,
  • Anne Grimbs,
  • Stefan Bornholdt,
  • Marc-Thorsten Hütt

DOI
https://doi.org/10.1038/s41467-017-00587-4
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 9

Abstract

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Although networks of interacting genes and metabolic reactions are interdependent, they have largely been treated as separate systems. Here the authors apply a statistical framework for interdependent networks to E. coli, and show that it is sensitive to gene and protein perturbations but robust against metabolic changes.