Author's View: a nuclear transcription factor relocalizing to mitochondria rescues cells from proteotoxic aggregates

Abstract

Mitochondrial proteostasis is essential for survival, and imbalances can result in severe human diseases. We identified a novel stress response triggered upon accumulation of proteotoxic aggregates in the mitochondrial matrix. Mitochondria-to-nucleus signaling results in a transcriptional response and translocation of a nuclear transcription factor into mitochondria to maintain mitochondrial gene expression.

Keywords

• mitochondria-to-nucleus communication
• dual targeting
• mitochondrial proteostasis
• protein biogenesis
• mitochondrial unfolded protein response