Molbank (Jan 2023)

1-{(1<i>S</i>,2<i>S</i>,4<i>R</i>)-7,7-Dimethyl-1-[(pyrrolidin-1-yl)methyl]bicyclo [2.2.1]heptan-2-yl}-1<i>H</i>-benzo[<i>d</i>]imidazole

  • Luka Ciber,
  • Franc Požgan,
  • Jurij Svete,
  • Bogdan Štefane,
  • Uroš Grošelj

DOI
https://doi.org/10.3390/M1538
Journal volume & issue
Vol. 2023, no. 1
p. M1538

Abstract

Read online

A three-step synthesis of 1-{(1S,2S,4R)-7,7-dimethyl-1-[(pyrrolidin-1-yl)methyl]bicyclo[2.2.1]heptan-2-yl}-1H-benzo[d]imidazole, prepared from camphor derived diamine, is disclosed. The absolute configuration at the chiral center bearing benzo[d]imidazole moiety was confirmed by NOESY. The structure of a newly synthesized compound was confirmed by 1H- and 13C-NMR, 2D NMR, IR spectroscopy, and high resolution mass-spectrometry.

Keywords