Manifestation of automaticity in the pulmonary-vein myocardium of rats with abdominal aorto-venocaval shunt

Shogo Hamaguchi; Yayoi Tsuneoka; Ayumi Tanaka; Masahiko Irie; Masato Tsuruta; Takahiro Nakayama; Iyuki Namekata; Mizuki Nada; Megumi Aimoto; Akira Takahara; Hikaru Tanaka

doi:10.1016/j.jphs.2015.07.041

Journal of Pharmacological Sciences (Aug 2015)

Manifestation of automaticity in the pulmonary-vein myocardium of rats with abdominal aorto-venocaval shunt

Shogo Hamaguchi,
Yayoi Tsuneoka,
Ayumi Tanaka,
Masahiko Irie,
Masato Tsuruta,
Takahiro Nakayama,
Iyuki Namekata,
Mizuki Nada,
Megumi Aimoto,
Akira Takahara,
Hikaru Tanaka

Affiliations

Shogo Hamaguchi: Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan
Yayoi Tsuneoka: Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan
Ayumi Tanaka: Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan
Masahiko Irie: Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan
Masato Tsuruta: Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan
Takahiro Nakayama: Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan
Iyuki Namekata: Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan
Mizuki Nada: Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan
Megumi Aimoto: Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan
Akira Takahara: Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan
Hikaru Tanaka: Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan

DOI: https://doi.org/10.1016/j.jphs.2015.07.041
Journal volume & issue: Vol. 128, no. 4
pp. 212 – 215

Abstract

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Effect of abdominal aorto-venocaval shunt (AVS) on the automaticity of the pulmonary-vein myocardium was studied in the rat. Spontaneous electrical activity was observed in one third of the isolated pulmonary-vein preparations from the AVS rats, but scarcely in those from sham-operated rats; the activity was induced by tertiapin and suppressed by carbachol or chelation of intracellular Ca2+. The evoked action potentials in AVS rats had less negative resting membrane potential and longer action potential duration than those in sham-operated rats. These results suggest that the automaticity of the rat pulmonary-vein myocardium is manifested under chronic volume overload.

Published in Journal of Pharmacological Sciences

ISSN: 1347-8613 (Print)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.sciencedirect.com/journal/journal-of-pharmacological-sciences

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