Nature Communications (Oct 2022)
Defining cellular complexity in human autosomal dominant polycystic kidney disease by multimodal single cell analysis
- Yoshiharu Muto,
- Eryn E. Dixon,
- Yasuhiro Yoshimura,
- Haojia Wu,
- Kohei Omachi,
- Nicolas Ledru,
- Parker C. Wilson,
- Andrew J. King,
- N. Eric Olson,
- Marvin G. Gunawan,
- Jay J. Kuo,
- Jennifer H. Cox,
- Jeffrey H. Miner,
- Stephen L. Seliger,
- Owen M. Woodward,
- Paul A. Welling,
- Terry J. Watnick,
- Benjamin D. Humphreys
Affiliations
- Yoshiharu Muto
- Division of Nephrology, Department of Medicine, Washington University in St. Louis
- Eryn E. Dixon
- Division of Nephrology, Department of Medicine, Washington University in St. Louis
- Yasuhiro Yoshimura
- Division of Nephrology, Department of Medicine, Washington University in St. Louis
- Haojia Wu
- Division of Nephrology, Department of Medicine, Washington University in St. Louis
- Kohei Omachi
- Division of Nephrology, Department of Medicine, Washington University in St. Louis
- Nicolas Ledru
- Division of Nephrology, Department of Medicine, Washington University in St. Louis
- Parker C. Wilson
- Department of Pathology and Immunology, Washington University in St. Louis
- Andrew J. King
- Chinook Therapeutics, Inc.
- N. Eric Olson
- Chinook Therapeutics, Inc.
- Marvin G. Gunawan
- Chinook Therapeutics, Inc.
- Jay J. Kuo
- Chinook Therapeutics, Inc.
- Jennifer H. Cox
- Chinook Therapeutics, Inc.
- Jeffrey H. Miner
- Division of Nephrology, Department of Medicine, Washington University in St. Louis
- Stephen L. Seliger
- Department of Medicine, University of Maryland School of Medicine
- Owen M. Woodward
- Department of Physiology, University of Maryland School of Medicine
- Paul A. Welling
- Johns Hopkins School of Medicine
- Terry J. Watnick
- Department of Medicine, University of Maryland School of Medicine
- Benjamin D. Humphreys
- Division of Nephrology, Department of Medicine, Washington University in St. Louis
- DOI
- https://doi.org/10.1038/s41467-022-34255-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
Autosomal dominant polycystic kidney disease (ADPKD) is a complicated disease that involves numerous cell types. Here the authors used a multiomics approach consisting of single nucleus transcriptomes and epigenomes to redefine cell states in ADPKD and to dissect the cellular interactions and molecular mechanisms of ADPKD.
