Discriminant Analysis of Rheumatoid Factor, Anti-Cyclic Citrullinated Peptide, and C-Reactive Protein for Rheumatoid Arthritis Patients

Abstract

Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by joint swelling, joint tenderness, and destruction of synovial joints, leading to severe disability and premature mortality with uncertain aetiology by significant morbidity and mortality. Prevalence of approximately 0.75% in India. About 40% diseased become work disabled within 5 years from onset of symptoms. Objectives: The study was conducted to determine the most parsimonious way to distinguish between groups and to test the theory by which cases are classified as predicted. Method: The study is based on 290 clinically suspected RA patients. Cross-sectional study design was used. Clinically suspected cases were referred by different OPD’s of Sir Sunderlal Hospital for screening. Result: RF, AntiCCP and CRP diagnosed RA 21.3%, 21.7% and 33.1% respectively as positive . 277/290 (92.1%) of respondents were classified correctly into ‘RA’ or ‘non-RA’ groups. Non-RA were classified with better accuracy (98.8%) than RA (58.3%). Interpretation & Conclusion: Early diagnosis of these high risk suspects will help in preventing from foremost disability. The quality of life may be approved of infected subjects by providing timely diagnosis and treatments and balanced nutritional and social supports.

Keywords

• Rheumatoid arthritis
• discriminant analysis
• C-Reactive Protein
• Arthritis