Nature Communications (Nov 2019)

Complex I is bypassed during high intensity exercise

  • Avlant Nilsson,
  • Elias Björnson,
  • Mikael Flockhart,
  • Filip J. Larsen,
  • Jens Nielsen

DOI
https://doi.org/10.1038/s41467-019-12934-8
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

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During high-intensity exercise, muscles convert glucose to lactate, in a process that is energetically less efficient than respiration. Here the authors develop a computational model based on muscle proteomic data showing that bypassing mitochondrial complex I increases ATP production rates, and validate these model predictions in an exercise test on 5 subjects.