Infection and Drug Resistance (Aug 2021)
Prevalence, Parasite Density and Determinants of Falciparum Malaria Among Febrile Children in Some Peri-Urban Communities in Southwestern Nigeria: A Cross-Sectional Study
Abstract
Oluwaseun Bunmi Awosolu,1,2 Zary Shariman Yahaya,1 Meor Termizi Farah Haziqah1 1School of Biological Sciences, Universiti Sains Malaysia, Penang, 11800 USM, Malaysia; 2Department of Biology, Federal University of Technology, Akure, NigeriaCorrespondence: Zary Shariman YahayaSchool of Biological Sciences, Universiti Sains Malaysia, Penang, 11800 USM, MalaysiaTel +60143497174Email [email protected]: Malaria remains a serious public health problem worldwide, particularly in tropical and subtropical regions, including Nigeria. This study investigates the prevalence, parasite density and determinants of malaria among symptomatic children in some peri-urban communities in southwestern Nigeria.Methods: This was a randomized cross-sectional and hospital-based study. The standard method of microscopy was employed. Thick and thin films were prepared and viewed under a light microscope to identify and quantify malaria parasites. A well-structured and pre-tested questionnaire was used to obtain the subject’s information on the demographic, socio-economic and environmental variables.Results: A total of 380 (71.7%) participants were infected with Plasmodium falciparum with a mean parasite density of 1857.11 parasite/μL of blood. Malaria prevalence and mean parasite density were significantly higher among male compared to their female counterparts [80.3% vs 61.4% and 2026.46 vs 1619.63 parasite/μL of blood]. Similarly, age group ≤ 5 years had the highest malaria prevalence (92.2%) and mean parasite density (2031.66 parasite/μL of blood) than other age groups (AOR 2.281, 95% CI: 1.187– 4.384, P < 0.05). The multivariate logistic analysis showed that malaria disease is significantly associated with having mother with no formal education (AOR 12.235, 95% CI: 3.253– 46.021, P < 0.05), having well and river as a major source of household water supply (AOR 13.810, 95% CI: 3.012– 63.314, P < 0.05 vs AOR 5.639, 95% CI: 1.455– 21.853, P < 0.05) and presence of stagnant water around home (AOR 5.22, 95% CI: 2.921– 9.332, P < 0.05). Furthermore, protective factors observed include ownership of mosquito bed net (AOR 0.474, 95% CI: 0.223– 1.008, P < 0.05) and distance of home to hospital (AOR 0.279, 95% CI: 0.158– 0.493, P < 0.05).Conclusion: Malaria remains a serious public health problem in the study area. Adopting integrated malaria control measures including educating parents on malaria prevention and control strategies, distributing mosquito bed nets, and establishing larvae source management program is highly imperative.Keywords: Akure, malaria, parasite density, Plasmodium falciparum, prevalence, risk factors
