Armaghane Danesh Bimonthly Journal (Jul 2019)

Effect of Aerobic Training and L-Carnitine Consumption on Some Oxidative Stress Factors in Diabetic Rat kidney

  • A Fakourian,
  • H Matinhomaee,
  • MA Azarbayjani,
  • P Farzanegi

Journal volume & issue
Vol. 24, no. 3
pp. 293 – 305

Abstract

Read online

Abstract Background & aim: The use of non-enzymatic antioxidants in food supplements and proper exercise can have a positive effect on decreasing oxidative stress by free radical hunting. The purpose of this study was to investigate the effect of aerobic training and consumption of l-carnitine on some of the oxidative stress factors in diabetic kidney. Methods: In the present experimental study, 45 male Wistar rats(200-300 gr) were randomly divided into six groups: 1) sham group, 2) healthy control group 3) diabetic control group, 4) diabetic group receiving l-carnitine, 5) diabetic group of aerobic training, 6) diabetic group of aerobic training and receiving l-carnitine. Rats were diabetic peritoneal injected with nicotinic amide and a single dose of STZ of 55 mg / kg body weight. Rats in the L-carnitine group received daily of 100 mg of l-carnitine orally. The aerobic exercise protocol included five sessions per week on the treadmill. Data were analyzed by two way ANOVA and Tukey post hoc test at P 0.05). However, six weeks of aerobic exercise had a significant effect on GPX factor in kidney tissue in diabetic rats (p=0.003). Moreover, supplementation and combined intervention of aerobic exercise and supplementation of l-carnitine did not have a significant effect on GPX factor of kidney tissue in diabetic rats (p>0.05) Conclusion: L-carnitine supplementation intake with regular exercise can have beneficial effects on the body, antioxidant defense system and decreases oxidative stress in rats with type 2 diabetes.

Keywords