npj Breast Cancer (Nov 2021)

Mammographic texture features associated with contralateral breast cancer in the WECARE Study

  • Gordon P. Watt,
  • Julia A. Knight,
  • Christine Lin,
  • Charles F. Lynch,
  • Kathleen E. Malone,
  • Esther M. John,
  • Leslie Bernstein,
  • Jennifer D. Brooks,
  • Anne S. Reiner,
  • Xiaolin Liang,
  • Meghan Woods,
  • Tuong L. Nguyen,
  • John L. Hopper,
  • Malcolm C. Pike,
  • Jonine L. Bernstein

DOI
https://doi.org/10.1038/s41523-021-00354-1
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 4

Abstract

Read online

Abstract To evaluate whether mammographic texture features were associated with second primary contralateral breast cancer (CBC) risk, we created a “texture risk score” using pre-treatment mammograms in a case–control study of 212 women with CBC and 223 controls with unilateral breast cancer. The texture risk score was associated with CBC (odds per adjusted standard deviation = 1.25, 95% CI 1.01–1.56) after adjustment for mammographic percent density and confounders. These results support the potential of texture features for CBC risk assessment of breast cancer survivors.