Benzyl isothiocyanate suppresses development of thyroid carcinoma by regulating both autophagy and apoptosis pathway
Rossella Basilotta,
Giovanna Casili,
Deborah Mannino,
Alessia Filippone,
Marika Lanza,
Anna Paola Capra,
Domenico Giosa,
Stefano Forte,
Lorenzo Colarossi,
Dorotea Sciacca,
Emanuela Esposito,
Irene Paterniti
Affiliations
Rossella Basilotta
Departement of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D’Alcontres 31, 98166 Messina, Italy
Giovanna Casili
Departement of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D’Alcontres 31, 98166 Messina, Italy
Deborah Mannino
Departement of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D’Alcontres 31, 98166 Messina, Italy
Alessia Filippone
Departement of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D’Alcontres 31, 98166 Messina, Italy
Marika Lanza
Departement of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D’Alcontres 31, 98166 Messina, Italy
Anna Paola Capra
Department of Clinical and Experimental Medicine, University of Messina, Viale Ferdinando Stagno D' Alcontres 31, 98166 Messina, ME, Italy
Domenico Giosa
Departement of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D’Alcontres 31, 98166 Messina, Italy
Stefano Forte
Istituto Oncologico del Mediterraneo, Via Penninazzo 7, 95029 Viagrande, Italy
Lorenzo Colarossi
Istituto Oncologico del Mediterraneo, Via Penninazzo 7, 95029 Viagrande, Italy
Dorotea Sciacca
Istituto Oncologico del Mediterraneo, Via Penninazzo 7, 95029 Viagrande, Italy
Emanuela Esposito
Departement of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D’Alcontres 31, 98166 Messina, Italy; Corresponding author
Irene Paterniti
Departement of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D’Alcontres 31, 98166 Messina, Italy
Summary: Anaplastic thyroid carcinoma (ATC) is the most aggressive type of thyroid cancer, characterized by rapid growth and invasion and poor prognosis. Due to its rarity and aggressive nature, ATC is a difficult condition to treat, thus knowledge of the mechanisms underlying its progression represents important research challenges. Benzyl isothiocyanate (BITC) is a natural compound that has shown promising anticancer properties. The aim of this study was to evaluate the antitumor effect of BITC in ATC, highlighting signaling pathways involved in BITC mechanism of action. This work included in vitro and in vivo studies. Results obtained indicate that BITC, both in vitro and in vivo, has the potential to slow the progression of ATC through interactions with autophagy, reduction in epithelial-mesenchymal transition (EMT) and attenuation of inflammation. In conclusion, this study identifies BITC as a compound worth further investigation for the development of new treatment strategies for this aggressive form of thyroid cancer.
