Journal of Cutaneous Immunology and Allergy (Aug 2023)

Possible role of the collagen type I alpha 1–platelet‐derived growth factor beta chain fusion gene in the development of dermatofibrosarcoma protuberans with fibrosarcomatous transformation

  • Fuminori Katsumata,
  • Koji Kamiya,
  • Hitomi Miyauchi,
  • Hirofumi Okada,
  • Atsuko Sato,
  • Takeo Maekawa,
  • Mayumi Komine,
  • Mamitaro Ohtsuki

DOI
https://doi.org/10.1002/cia2.12297
Journal volume & issue
Vol. 6, no. 4
pp. 129 – 131

Abstract

Read online

Abstract Dermatofibrosarcoma protuberans with fibrosarcomatous transformation (DFSP‐FS) is a rare variant, with higher rates of recurrence and metastasis than DFSP. Detection of the collagen type I alpha 1 (COL1A1)–platelet‐derived growth factor beta chain (PDGFB) fusion gene is useful for the diagnosis of DFSP. In this letter, we report a case of DFSP‐FS, focusing on the expression of the COL1A1‐PDGFB fusion gene in the lesions. Increased expression of the COL1A1‐PDGFB fusion gene may be associated with fibrosarcomatous changes during the pathogenesis of DFSP.

Keywords