Frontiers in Bioscience-Landmark (Oct 2020)

Environmental parasitology and its impact on the host nueroimmunoendocrine network

  • Carmen T Gomez de Leon,
  • Pedro Ostoa-Saloma,
  • Mariana Segovia-Mendoza,
  • Victor H Del Rio-Araiza,
  • Jorge Morales-Montor

DOI
https://doi.org/10.2741/4900
Journal volume & issue
Vol. 26, no. 3
pp. 431 – 443

Abstract

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The communication between neuroendocrine and immune system maintains a bidirectional complex network. Both systems jointly act during a parasite infection to maintain homeostasis and to eliminate such pathogens. Parasites interfere with the synthesis, secretion, metabolism, action, and elimination of endogenous hormones, as well as with the immune system in the host. Here, we aim to address as how parasite colonization disrupts the normal homeostasis of endocrine organs of the host, likely due to the exacerbated immune response, or by the impact of the parasite directly affecting endocrine tissues.

Keywords