A measure of treatment response: patient and physician satisfaction with traditional NSAIDs for osteoarthritis control

Abstract

Stephanie D Taylor,1 Sharlette V Everett,1 Thomas N Taylor,2 Douglas J Watson,3 Gavin Taylor-Stokes4 1Global Health Outcomes, Merck Sharp and Dohme Corp, Whitehouse Station, NJ, USA; 2Pharmacy Practice, Wayne State University, Detroit, MI, USA; 3Epidemiology, Merck Sharp and Dohme Corp, Upper Gwynedd, PA, USA; 4Adelphi Real World, Macclesfield, UK Purpose: The clinical response to traditional nonsteroidal anti-inflammatory drugs (tNSAIDs) varies substantially. The objective of this study was to describe physicians’ and patients’ perceptions of response to tNSAIDs as measured by satisfaction with control of patients’ osteoarthritis (OA). Patients and methods: A cross-sectional survey was undertaken in 2009 in Germany, Spain, and the UK. Linked physician and patient questionnaires collected data on OA management, degree of pain and disability, and satisfaction with OA control. Results: The study included 363 treating physicians and 713 patients receiving tNSAIDs. Patient mean (standard deviation) age was 65.5 (11.0) years (range 36–94 years); 60% were women; 86% were white; and one-quarter were obese. Dissatisfaction with control of patients’ OA was expressed by physicians or their patients, or both, for 51% of patients, including 208 patients (31%) with mild OA and 478 patients (60%) with moderate or severe OA. Overall, 37% of patients reported dissatisfaction and 34% had a physician who reported dissatisfaction. Patient and physician assessments were the same in 70% of cases; Cohen’s κ coefficient was 0.34 (95% confidence interval 0.26–0.41), indicating fair agreement. Of those reporting dissatisfaction, most physicians (79%) and patients (64%) believed that the current control was the best that could be achieved. The most common reasons for which physicians reported dissatisfaction were inadequate response (56%), side effects (11.1%), and poor tolerance (7.8%). Conclusion: One-half of patients or their treating physicians were dissatisfied with the control of OA provided by tNSAID therapy; moreover, most believed it was the best control that could be achieved. Keywords: cross-sectional, dissatisfaction, pain, survey