Frontiers in Cell and Developmental Biology (Mar 2023)

Annexin A protein family: Focusing on the occurrence, progression and treatment of cancer

  • Huhu Zhang,
  • Zhe Zhang,
  • Tingting Guo,
  • Guang Chen,
  • Guoxiang Liu,
  • Qinghang Song,
  • Guichun Li,
  • Fenghua Xu,
  • Xiaolei Dong,
  • Fanghao Yang,
  • Can Cao,
  • Di Zhong,
  • Shuang Li,
  • Ya Li,
  • Mengjun Wang,
  • Bing Li,
  • Bing Li,
  • Lina Yang

DOI
https://doi.org/10.3389/fcell.2023.1141331
Journal volume & issue
Vol. 11

Abstract

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The annexin A (ANXA) protein family is a well-known tissue-specific multigene family that encodes Ca2+ phospholipid-binding proteins. A considerable amount of literature is available on the abnormal expression of ANXA proteins in various malignant diseases, including cancer, atherosclerosis and diabetes. As critical regulatory molecules in cancer, ANXA proteins play an essential role in cancer progression, proliferation, invasion and metastasis. Recent studies about their structure, biological properties and functions in different types of cancers are briefly summarised in this review. We further discuss the use of ANXA as new class of targets in the clinical diagnosis and treatment of cancer.

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