Ultrasound assisted Mizoroki–Heck reaction catalyzed by Pd/C: Synthesis of 3-vinyl indoles as potential cytotoxic agents

S. Bhavani; Mohd Ashraf Ashfaq; D. Rambabu; M.V. Basaveswara Rao; Manojit Pal

Arabian Journal of Chemistry (Dec 2019)

Ultrasound assisted Mizoroki–Heck reaction catalyzed by Pd/C: Synthesis of 3-vinyl indoles as potential cytotoxic agents

S. Bhavani,
Mohd Ashraf Ashfaq,
D. Rambabu,
M.V. Basaveswara Rao,
Manojit Pal

Affiliations

S. Bhavani: Department of Chemistry, K.L. University, Vaddeswaram, Guntur 522502, Andhra Pradesh, India
Mohd Ashraf Ashfaq: Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Hyderabad 500046, India
D. Rambabu: Department of Chemistry and the National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Be’er-Sheva 84105, Israel
M.V. Basaveswara Rao: Department of Chemistry, Krishna University, Machilipatnam 521001, Andhra Pradesh, India; Corresponding authors. Tel.: +91 40 6657 1500.
Manojit Pal: Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Hyderabad 500046, India; Corresponding authors. Tel.: +91 40 6657 1500.

Journal volume & issue: Vol. 12, no. 8
pp. 3836 – 3846

Abstract

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The Pd/C–PPh3 catalyst system facilitated the C–C bond forming reaction between 3-iodo-1-methyl-1H-indole and various terminal alkenes under ultrasound irradiation. The present ultrasound assisted Mizoroki–Heck coupling afforded a number of 3-vinyl indole derivatives in good to acceptable yields. Two of these indole derivatives showed cytotoxic activities against breast cancer cell lines. Keywords: Indole, Alkenes, Pd/C, Ultrasound, Cytotoxicity

Published in Arabian Journal of Chemistry

ISSN: 1878-5352 (Print)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Chemistry
Website: http://www.journals.elsevier.com/arabian-journal-of-chemistry/

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