Prospective Comparative Study between Silodosin 8 mg Versus Combination of Tadalafil 5mg and Silodosin 4mgfor treatment of Lower Urinary Tract Symptoms related to Benign Prostatic Hyperplasia

Abstract

Background:In men, lower urinary tract symptoms (LUTS) are associated with benign prostatichyperplasia (BPH). Therapeutic options aim to relax prostate smooth muscle and/or reduce prostate enlargement. Objectives:To evaluate the efficacy of Silodosin 8 mgalone versus the combinationof Tadalafil 5mg and Silodosin 4 mgfor treatment of LUTS related to BPH. Patients and methods: About 203 patients with LUTS of BPH who completed the study up protocolpresented to our department classified into two groups group A (101 patients) received Silodosin 8 mg, group B (102 patients) received the combination of Tadalafil 5mg and Silodosin 4 mg. All results recorded and analyzed with Statistical Package for Social Science® (SPSS) and Microsoft Excel 2010. Results: The IPSS, QOL, IIEF score, Q-max and PVR showed significantly greater improvement in the combination of Tadalafil 5mg with Silodosin 4mg than monotherapy of Silodosin 8mg. Conclusions:Despite Silodosin 8mg is well-tolerated and effective treatment option in men with LUTS of BPH, butthe combination of tadalafil 5m and Silodosin 4mg is more effective and feasible for these patients.

Keywords

• luts of bph; tadalafil 5mg; silodosin 4mg; silodosin 8mg