RUFY3 links Arl8b and JIP4-Dynein complex to regulate lysosome size and positioning

Gaurav Kumar; Prateek Chawla; Neha Dhiman; Sanya Chadha; Sheetal Sharma; Kanupriya Sethi; Mahak Sharma; Amit Tuli

doi:10.1038/s41467-022-29077-y

Nature Communications (Mar 2022)

RUFY3 links Arl8b and JIP4-Dynein complex to regulate lysosome size and positioning

Gaurav Kumar,
Prateek Chawla,
Neha Dhiman,
Sanya Chadha,
Sheetal Sharma,
Kanupriya Sethi,
Mahak Sharma,
Amit Tuli

Affiliations

Gaurav Kumar: Divison of Cell Biology and Immunology, CSIR-Institute of Microbial Technology (IMTECH)
Prateek Chawla: Department of Biological Sciences, Indian Institute of Science Education and Research (IISER)
Neha Dhiman: Department of Biological Sciences, Indian Institute of Science Education and Research (IISER)
Sanya Chadha: Divison of Cell Biology and Immunology, CSIR-Institute of Microbial Technology (IMTECH)
Sheetal Sharma: Divison of Cell Biology and Immunology, CSIR-Institute of Microbial Technology (IMTECH)
Kanupriya Sethi: Divison of Cell Biology and Immunology, CSIR-Institute of Microbial Technology (IMTECH)
Mahak Sharma: Department of Biological Sciences, Indian Institute of Science Education and Research (IISER)
Amit Tuli: Divison of Cell Biology and Immunology, CSIR-Institute of Microbial Technology (IMTECH)

DOI: https://doi.org/10.1038/s41467-022-29077-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 21

Abstract

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Lysosomes move along microtubule tracks, and Arl8b is known to stimulate their anterograde transport. Here, the authors identified RUFY3 as an Arl8b effector that interacts with dynein-dynactin to drive retrograde transport and perinuclear lysosome positioning.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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