Can Biomarkers be used for Prognosis Prediction in Patients with Acute Mesenteric Ischemia?

Abstract

Introduction: Acute mesenteric ischemia (AMI) is a severe clinical condition that leads to intestinal ischemia and necrosis due to acute blockage of the mesenteric arteries. The mortality rate of AMI is still high, and early diagnosis and treatment are lifesaving. This study provides an overview of the biochemical parameters used to determine the prognosis of AMI patients. Methods: This was an observational and single-center study. Demographic data, vital signs, comorbidities, laboratory tests, operative status, length of hospital stay, and outcome information of patients diagnosed with AMI were recorded. Results: Twenty-eight (41.2%) female and 40 (58.8%) male patients were included in the study. Of the patients diagnosed with AMI, 45 (66.2%) underwent surgery. Twenty-six patients (38.2%) had a fatal outcome. The area under the curve (AUC) values for blood urea nitrogen (BUN)/albumin [0.850 (0.743-0.925)] and lactate/albumin [0.753 (0.633-0.849)] were statistically significant (p<0.001) for the outcome. The AUC analysis for C-reactive protein/albumin [0.654 (0.529-0.765)] indicated a significant relationship for surgical settings (p<0.05). In the intensive care unit setting, all ratios were statistically significant. Conclusion: This study shows that the BUN/albumin ratio is a robust prognostic indicator of patients with AMI and guides clinicians’ decision-making. However, further studies are required to confirm these data.

Keywords

• acute mesenteric ischemia
• early prediction
• bun
• albumin