Nature Communications (Aug 2020)

Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo

  • Ines Cabrita,
  • Andre Kraus,
  • Julia Katharina Scholz,
  • Kathrin Skoczynski,
  • Rainer Schreiber,
  • Karl Kunzelmann,
  • Björn Buchholz

DOI
https://doi.org/10.1038/s41467-020-18104-5
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

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Polycystic kidney disease (PKD) is characterized by the formation of large renal cysts, which lead to a decline in renal function. Here the authors show that genetic and chemical inhibition of TMEM16A largely reduces cyst enlargement in an in vivo model of autosomal dominant PKD.