Novel recruitment approaches and operational results for a statewide population Cohort for cancer research: The Healthy Oregon Project

Zhenzhen Zhang; Autumn Shafer; Katie Johnson-Camacho; Andrew Adey; Pavana Anur; Kim A. Brown; Casey Conrad; Rachel Crist; Paige E. Farris; Christina A. Harrington; Lisa K. Marriott; Asia Mitchell; Brian O’Roak; Vanessa Serrato; C. Sue Richards; Paul T. Spellman; Jackilen Shannon

doi:10.1017/cts.2024.9

Journal of Clinical and Translational Science (Jan 2024)

Novel recruitment approaches and operational results for a statewide population Cohort for cancer research: The Healthy Oregon Project

Zhenzhen Zhang,
Autumn Shafer,
Katie Johnson-Camacho,
Andrew Adey,
Pavana Anur,
Kim A. Brown,
Casey Conrad,
Rachel Crist,
Paige E. Farris,
Christina A. Harrington,
Lisa K. Marriott,
Asia Mitchell,
Brian O’Roak,
Vanessa Serrato,
C. Sue Richards,
Paul T. Spellman,
Jackilen Shannon

Affiliations

Zhenzhen Zhang: ORCiD; Division of Oncological Sciences, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA
Autumn Shafer: School of Journalism and Communication, University of Oregon, Eugene, OR, USA
Katie Johnson-Camacho: Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA Cancer Early Detection Advanced Research Center, Oregon Health and Science University, Portland, OR, USA
Andrew Adey: Division of Oncological Sciences, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA Cancer Early Detection Advanced Research Center, Oregon Health and Science University, Portland, OR, USA Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR, USA Knight Cardiovascular Institute, Oregon Health and Science University, Portland, OR, USA
Pavana Anur: Cancer Early Detection Advanced Research Center, Oregon Health and Science University, Portland, OR, USA
Kim A. Brown: Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA Oregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland, OR, USA
Casey Conrad: Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA Cancer Early Detection Advanced Research Center, Oregon Health and Science University, Portland, OR, USA
Rachel Crist: Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA Cancer Early Detection Advanced Research Center, Oregon Health and Science University, Portland, OR, USA
Paige E. Farris: Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA OHSU-PSU School of Public Health, Oregon Health & Science University, Portland, OR, USA
Christina A. Harrington: Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR, USA Gene Profiling Shared Resource, Oregon Health & Science University, Portland, OR, USA
Lisa K. Marriott: OHSU-PSU School of Public Health, Oregon Health & Science University, Portland, OR, USA
Asia Mitchell: Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR, USA
Brian O’Roak: Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR, USA
Vanessa Serrato: Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA
C. Sue Richards: Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR, USA Knight Diagnostic Laboratories, Oregon Health & Science University, Portland, OR, USA
Paul T. Spellman: ORCiD; Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA Department of Human Genetics, University of California Los Angeles, Los Angeles, CA, USA Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA Cancer Early Detection Advanced Research Center, Oregon Health and Science University, Portland, OR, USA
Jackilen Shannon: ORCiD; Division of Oncological Sciences, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA Cancer Early Detection Advanced Research Center, Oregon Health and Science University, Portland, OR, USA

DOI: https://doi.org/10.1017/cts.2024.9
Journal volume & issue: Vol. 8

Abstract

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Abstract Background: Cancer health research relies on large-scale cohorts to derive generalizable results for different populations. While traditional epidemiological cohorts often use costly random sampling or self-motivated, preselected groups, a shift toward health system-based cohorts has emerged. However, such cohorts depend on participants remaining within a single system. Recent consumer engagement models using smartphone-based communication, driving projects, and social media have begun to upend these paradigms. Methods: We initiated the Healthy Oregon Project (HOP) to support basic and clinical cancer research. HOP study employs a novel, cost-effective remote recruitment approach to effectively establish a large-scale cohort for population-based studies. The recruitment leverages the unique email account, the HOP website, and social media platforms to direct smartphone users to the study app, which facilitates saliva sample collection and survey administration. Monthly newsletters further facilitate engagement and outreach to broader communities. Results: By the end of 2022, the HOP has enrolled approximately 35,000 participants aged 18–100 years (median = 44.2 years), comprising more than 1% of the Oregon adult population. Among those who have app access, ∼87% provided consent to genetic screening. The HOP monthly email newsletters have an average open rate of 38%. Efforts continue to be made to improve survey response rates. Conclusion: This study underscores the efficacy of remote recruitment approaches in establishing large-scale cohorts for population-based cancer studies. The implementation of the study facilitates the collection of extensive survey and biological data into a repository that can be broadly shared and supports collaborative clinical and translational research.

Published in Journal of Clinical and Translational Science

ISSN: 2059-8661 (Online)
Publisher: Cambridge University Press
Country of publisher: United Kingdom
LCC subjects: Medicine
Website: https://www.cambridge.org/core/journals/journal-of-clinical-and-translational-science

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