Drug Design, Development and Therapy (Sep 2019)
The Efficacy And Safety Of Apatinib Treatment For Patients With Metastatic Or Recurrent Cervical Cancer: A Retrospective Study
Abstract
Jiangtao Yu,1,2,* Ziwen Xu,3,* Anyang Li,2 Jindi Zhang,2 Yi Wang,4 Hongqin Zhao,2 Haiyan Zhu1,2 1Department of Gynecology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 200126, People’s Republic of China; 2Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, People’s Republic of China; 3Department of Medicine, Wenzhou Medical University, Wenzhou 325015, People’s Republic of China; 4Department of Gynecology, Wenzhou Oncology Hospital, Wenzhou 325000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Haiyan ZhuDepartment of Gynecology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 200126, People’s Republic of ChinaTel +86 137584652255Email [email protected]: This study was performed to assess the efficacy and safety of apatinib in patients with metastatic or recurrent cervical cancer.Methods: Twenty-six patients with metastatic or recurrent cervical cancer and treated with apatinib until progressive disease or unacceptable toxicity were included in this multicenter, retrospective, observational study from January 2016 to April 2018. The primary end point was progression free survival (PFS). Secondary end points included overall survival (OS), objective response rate (ORR), disease control rate (DCR), and toxicity. Toxicities were assessed according to Common Terminology Criteria for Adverse Events.Results: A total of 26 metastatic or recurrent cervical cancer patients were enrolled in this study. No complete response (CR) occurred, 4 patients (15.4%) showed partial response (PR), 11 patients (42.3%) had stable disease (SD), and 11 patients (42.3%) had progressive disease (PD), with DCR of 57.7% and ORR of 15.4%. Median progression-free survival (PFS) was 3.0 months (95% confidence interval [CI]: 0–6.3 months) and overall survival (OS) was 7.0 months (95% CI: 5.1–8.9 months) respectively. The most common adverse effects were hand-foot syndrome (50.0%), secondary hypertension (26.9%) and fatigue (26.9%). Three patients discontinued treatment due to grade 3 toxicities (one case for hand-foot syndrome, two cases for diarrhea) and 6 patients required dose reduction because of adverse effects.Conclusion: Apatinib seems active in heavily-pretreated metastatic or recurrent cervical cancer. The adverse effects were moderate but manageable.Keywords: epidermal growth factor receptor, apatinib, cervical cancer, metastatic or recurrent, efficacy
