Nature Communications (Jan 2019)
Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway
- Rajbir Singh,
- Sandeep Chandrashekharappa,
- Sobha R. Bodduluri,
- Becca V. Baby,
- Bindu Hegde,
- Niranjan G. Kotla,
- Ankita A. Hiwale,
- Taslimarif Saiyed,
- Paresh Patel,
- Matam Vijay-Kumar,
- Morgan G. I. Langille,
- Gavin M. Douglas,
- Xi Cheng,
- Eric C. Rouchka,
- Sabine J. Waigel,
- Gerald W. Dryden,
- Houda Alatassi,
- Huang-Ge Zhang,
- Bodduluri Haribabu,
- Praveen K. Vemula,
- Venkatakrishna R. Jala
Affiliations
- Rajbir Singh
- Department of Microbiology and Immunology, James Graham Brown Cancer Center, University of Louisville
- Sandeep Chandrashekharappa
- Institute for Stem Cell Biology and Regenerative Medicine (inStem), GKVK campus
- Sobha R. Bodduluri
- Department of Microbiology and Immunology, James Graham Brown Cancer Center, University of Louisville
- Becca V. Baby
- Department of Microbiology and Immunology, James Graham Brown Cancer Center, University of Louisville
- Bindu Hegde
- Department of Microbiology and Immunology, James Graham Brown Cancer Center, University of Louisville
- Niranjan G. Kotla
- Institute for Stem Cell Biology and Regenerative Medicine (inStem), GKVK campus
- Ankita A. Hiwale
- Institute for Stem Cell Biology and Regenerative Medicine (inStem), GKVK campus
- Taslimarif Saiyed
- Centre for Cellular and Molecular Platforms (C-CAMP), GKVK campus
- Paresh Patel
- Centre for Cellular and Molecular Platforms (C-CAMP), GKVK campus
- Matam Vijay-Kumar
- Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences
- Morgan G. I. Langille
- Department of Pharmacology, Dalhousie University
- Gavin M. Douglas
- Department of Pharmacology, Dalhousie University
- Xi Cheng
- Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences
- Eric C. Rouchka
- Computer Engineering and Computer Science, Kentucky Biomedical Research Infrastructure Network, University of Louisville
- Sabine J. Waigel
- Department of Medicine, University of Louisville
- Gerald W. Dryden
- Department of Medicine, University of Louisville
- Houda Alatassi
- Department of Pathology, University of Louisville
- Huang-Ge Zhang
- Department of Microbiology and Immunology, James Graham Brown Cancer Center, University of Louisville
- Bodduluri Haribabu
- Department of Microbiology and Immunology, James Graham Brown Cancer Center, University of Louisville
- Praveen K. Vemula
- Institute for Stem Cell Biology and Regenerative Medicine (inStem), GKVK campus
- Venkatakrishna R. Jala
- Department of Microbiology and Immunology, James Graham Brown Cancer Center, University of Louisville
- DOI
- https://doi.org/10.1038/s41467-018-07859-7
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 18
Abstract
Urolithins are microbial metabolites derived from food polyphenols. Here, Singh et al. show that urolithin A and a synthetic analogue enhance gut barrier function via Nrf2-dependent pathways and mitigate inflammation and colitis in mice, highlighting a potential application for inflammatory bowel diseases.
