Nature Communications (Jan 2021)
A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization
- Jue-Sheng Ong,
- Suzanne C. Dixon-Suen,
- Xikun Han,
- Jiyuan An,
- Esophageal Cancer Consortium,
- 23 and Me Research Team,
- Upekha Liyanage,
- Jean-Cluade Dusingize,
- Johannes Schumacher,
- Ines Gockel,
- Anne Böhmer,
- Janusz Jankowski,
- Claire Palles,
- Tracy O’Mara,
- Amanda Spurdle,
- Matthew H. Law,
- Mark M. Iles,
- Paul Pharoah,
- Andrew Berchuck,
- Wei Zheng,
- Aaron P. Thrift,
- Catherine Olsen,
- Rachel E. Neale,
- Puya Gharahkhani,
- Penelope M. Webb,
- Stuart MacGregor
Affiliations
- Jue-Sheng Ong
- Statistical Genetics Group, Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute
- Suzanne C. Dixon-Suen
- Cancer Epidemiology Division, Cancer Council Victoria
- Xikun Han
- Statistical Genetics Group, Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute
- Jiyuan An
- Institute for Future Environments, Queensland University of Technology, QLD
- Esophageal Cancer Consortium
- 23 and Me Research Team
- Upekha Liyanage
- Cancer and Population Studies Group, Population Health Department, QIMR Berghofer Medical Research Institute
- Jean-Cluade Dusingize
- Cancer Control Group, Population Health Department, QIMR Berghofer Medical Research Institute
- Johannes Schumacher
- Institute of Human Genetics, Philipps University of Marburg
- Ines Gockel
- Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital Leipzig
- Anne Böhmer
- Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn
- Janusz Jankowski
- Centre for Medicine and Health Sciences, University of Arab Emirates University
- Claire Palles
- Institute of Cancer and Genomic Sciences, University of Birmingham
- Tracy O’Mara
- Molecular Cancer Epidemiology Group, QIMR Berghofer Medical Research Institute
- Amanda Spurdle
- Molecular Cancer Epidemiology Group, QIMR Berghofer Medical Research Institute
- Matthew H. Law
- Statistical Genetics Group, Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute
- Mark M. Iles
- Leeds Institute for Data Analytics, University of Leeds
- Paul Pharoah
- Department of Public Health and Primary Care, University of Cambridge
- Andrew Berchuck
- Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Duke University Medical Center
- Wei Zheng
- Division of Epidemiology, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
- Aaron P. Thrift
- Section of Epidemiology and Population Sciences, Department of Medicine, and Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine
- Catherine Olsen
- Faculty of Medicine, University of Queensland
- Rachel E. Neale
- Cancer Aetiology and Prevention Group, Population Health Department, QIMR Berghofer Medical Research Institute
- Puya Gharahkhani
- Statistical Genetics Group, Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute
- Penelope M. Webb
- Gynaecological Cancer Group, Population Health Department, QIMR Berghofer Medical Research Institute
- Stuart MacGregor
- Statistical Genetics Group, Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute
- DOI
- https://doi.org/10.1038/s41467-020-20368-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 10
Abstract
Studies of the genetic association between vitamin D and cancer risk have typically been underpowered. Here the authors analyse this using Mendelian Randomisation with more than 70 vitamin D variants obtained from the UK Biobank and large-scale data from various consortia, confirming null associations between vitamin D and most cancers.
