Nature Communications (2021-01-01)

A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization

  • Jue-Sheng Ong,
  • Suzanne C. Dixon-Suen,
  • Xikun Han,
  • Jiyuan An,
  • Esophageal Cancer Consortium,
  • 23 and Me Research Team,
  • Upekha Liyanage,
  • Jean-Cluade Dusingize,
  • Johannes Schumacher,
  • Ines Gockel,
  • Anne Böhmer,
  • Janusz Jankowski,
  • Claire Palles,
  • Tracy O’Mara,
  • Amanda Spurdle,
  • Matthew H. Law,
  • Mark M. Iles,
  • Paul Pharoah,
  • Andrew Berchuck,
  • Wei Zheng,
  • Aaron P. Thrift,
  • Catherine Olsen,
  • Rachel E. Neale,
  • Puya Gharahkhani,
  • Penelope M. Webb,
  • Stuart MacGregor

DOI
https://doi.org/10.1038/s41467-020-20368-w
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 10

Abstract

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Studies of the genetic association between vitamin D and cancer risk have typically been underpowered. Here the authors analyse this using Mendelian Randomisation with more than 70 vitamin D variants obtained from the UK Biobank and large-scale data from various consortia, confirming null associations between vitamin D and most cancers.