Towards a Synthesis of Vigabatrin Using Glycal Chemistry

Abstract

Application of the Ferrier rearrangement led to a novel carbohydrate based synthetic route to 4-aminohexenoic acid viz. (R) and (S)-vigabatrin. The potential of D- glucose or D-galactose as the chiral starting materials for the synthesis of (R) and (S)- vigabatrin has been explored.

Keywords

• Vigabatrin
• GABA-T
• γ-aminobutyric acid
• 4-amino-5-hexenoic acid
• Ferrier rearrangement
• glycal.