Viruses
(Apr 2024)
Influenza Virus Genomic Surveillance, Arizona, USA, 2023–2024
Rabia Maqsood,
Matthew F. Smith,
LaRinda A. Holland,
Regan A. Sullins,
Steven C. Holland,
Michelle Tan,
Gabrielle M. Hernandez Barrera,
Alexis W. Thomas,
Mario Islas,
Joanna L. Kramer,
Lora Nordstrom,
Mary Mulrow,
Michael White,
Vel Murugan,
Efrem S. Lim
Affiliations
Rabia Maqsood
Center for Fundamental and Applied Microbiomics, Biodesign Institute, Arizona State University, Tempe, AZ 85281, USA
Matthew F. Smith
Center for Fundamental and Applied Microbiomics, Biodesign Institute, Arizona State University, Tempe, AZ 85281, USA
LaRinda A. Holland
Center for Fundamental and Applied Microbiomics, Biodesign Institute, Arizona State University, Tempe, AZ 85281, USA
Regan A. Sullins
Center for Fundamental and Applied Microbiomics, Biodesign Institute, Arizona State University, Tempe, AZ 85281, USA
Steven C. Holland
Center for Fundamental and Applied Microbiomics, Biodesign Institute, Arizona State University, Tempe, AZ 85281, USA
Michelle Tan
Virginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ 85281, USA
Gabrielle M. Hernandez Barrera
Virginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ 85281, USA
Alexis W. Thomas
Virginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ 85281, USA
Mario Islas
Arizona State University Health Services, Tempe, AZ 85281, USA
Joanna L. Kramer
Division of Primary, Complex, and Adolescent Medicine, Phoenix Children’s Hospital, Phoenix, AZ 85016, USA
Lora Nordstrom
Valleywise Health Medical Center, Phoenix, AZ 85008, USA
Mary Mulrow
Valleywise Health Medical Center, Phoenix, AZ 85008, USA
Michael White
Valleywise Health Medical Center, Phoenix, AZ 85008, USA
Vel Murugan
Virginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ 85281, USA
Efrem S. Lim
Center for Fundamental and Applied Microbiomics, Biodesign Institute, Arizona State University, Tempe, AZ 85281, USA
DOI
https://doi.org/10.3390/v16050692
Journal volume & issue
Vol. 16,
no. 5
Abstract
Read online
Influenza viruses are constantly evolving and are therefore monitored worldwide in the hope to reduce the burden of disease by annual updates to vaccine recommendations. We conducted genomic sequencing of 110 influenza A and 30 influenza B viruses from specimens collected between October 2023 and February 2024 in Arizona, USA. We identified mutations in the hemagglutinin (HA) antigenic sites as well as the neuraminidase (NA) gene in our samples. We also found no unique HA and NA mutations in vaccinated yet influenza-infected individuals. Real-time genomic sequencing surveillance is important to ensure influenza vaccine effectiveness.
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