Antioxidant, and enhanced flexible nano porous scaffolds for bone tissue engineering applications

Abstract

Abstract Three‐dimensional bioactive, antioxidant, and porous nanocomposite scaffolds are inevitable to avoid dependency and disability in the life cycle. Herein, we develop a facile fabrication protocol of nano porous zinc doped hydroxyapatite (Zn‐HAp) scaffold enhanced by polysaccharide polymeric structure for bone tissue engineering applications. The bioactive nano scaffold exhibit opens porous assembly that sustains its flexible and robust nature and promotes efficient linking capability. Moreover, nano scaffold geometry and its porosity were controlled efficiently in various concentrations of zinc doped hydroxyapatite (Zn‐HAp) nanoparticles. Indeed, the composite scaffolds are retained in a dry shape with a suitable load‐bearing strength adjacent to the cancellous bone. The presence of zinc doped hydroxyapatite in the polymeric matrix of nano scaffold regulates its antibacterial response against different bacterial strains owing to its oxidative stress nature. The antioxidant and biocompatibility of nano‐scaffolds were investigated by DPPH (1,1‐diphenyl‐2‐picrylhydrazyl) scavenging behavior, the scavenging activity of ABTS (2,2‐azino‐bis‐3‐ethylbenzthiazoline‐ 6‐sulphonic acid) radical, and iron‐chelating potential. The observed results reveal that polysaccharide‐dependent porous geometry possesses adequate biocompatibility, radical scavenging behavior, and excellent antibacterial properties that validate it as a suitable candidate material for bone tissue implantation. The unprecedented radical scavenging and antioxidant bioactive nanocomposite scaffold are all set to reshape the future bone tissue implantation.

Keywords

• antioxidant
• anti‐swelling
• biocompatible
• bone tissue engineering
• robust scaffold