Generation of an induced pluripotent stem cell line (PNUYHi002-A) from a patient with Alzheimer’s disease carrying PRNP M232R variant

Mi Kyoung Kim; Yoon Kim; Nayeon Lee; Hye-Ji Moon; Jae-Hyeok Lee; Eun-Joo Kim; Yong Jun Kim; Jae-Ho Kim; Na-Yeon Jung

Stem Cell Research (Apr 2024)

Generation of an induced pluripotent stem cell line (PNUYHi002-A) from a patient with Alzheimer’s disease carrying PRNP M232R variant

Mi Kyoung Kim,
Yoon Kim,
Nayeon Lee,
Hye-Ji Moon,
Jae-Hyeok Lee,
Eun-Joo Kim,
Yong Jun Kim,
Jae-Ho Kim,
Na-Yeon Jung

Affiliations

Mi Kyoung Kim: Department of Neurology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Gyeongsangnam-do, Republic of Korea; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Gyeongsangnam-do, Republic of Korea
Yoon Kim: Department of Neurology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Gyeongsangnam-do, Republic of Korea; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Gyeongsangnam-do, Republic of Korea
Nayeon Lee: Convergence Stem Cell Research Center, Medical Research Institute, Pusan National University School of Medicine, Yangsan, Gyeongsangnam-do, Republic of Korea; Department of Physiology, Pusan National University School of Medicine, Yangsan, Gyeongsangnam-do, Republic of Korea
Hye-Ji Moon: Convergence Stem Cell Research Center, Medical Research Institute, Pusan National University School of Medicine, Yangsan, Gyeongsangnam-do, Republic of Korea; Department of Physiology, Pusan National University School of Medicine, Yangsan, Gyeongsangnam-do, Republic of Korea
Jae-Hyeok Lee: Department of Neurology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Gyeongsangnam-do, Republic of Korea; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Gyeongsangnam-do, Republic of Korea
Eun-Joo Kim: Department of Neurology, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Republic of Korea
Yong Jun Kim: Department of Pathology, College of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea
Jae-Ho Kim: Convergence Stem Cell Research Center, Medical Research Institute, Pusan National University School of Medicine, Yangsan, Gyeongsangnam-do, Republic of Korea; Department of Physiology, Pusan National University School of Medicine, Yangsan, Gyeongsangnam-do, Republic of Korea
Na-Yeon Jung: Department of Neurology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Gyeongsangnam-do, Republic of Korea; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Gyeongsangnam-do, Republic of Korea; Corresponding author at: Department of Neurology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and Technology, 20, Geumo-ro, Mulgeum-eup, Yangsan-si, Gyeongsangnam-do, 50612, Republic of Korea.

Journal volume & issue: Vol. 76
p. 103361

Abstract

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We generated a human induced pluripotent stem cell (iPSC) line from the peripheral blood mononuclear cells isolated from a 59-year-old male patient with Alzheimer’s disease (AD). The iPSC line was meticulously characterized to confirm its pluripotency, absence of transgenes, and normal karyotype. The unexpected discovery of the M232R variant in PRNP makes this cell line a valuable resource for investigating AD pathogenesis.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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