Spermidine rejuvenates T lymphocytes and restores anticancer immunosurveillance in aged mice

Abstract

Writing in Science, Al Habsi et al. show that spermidine boosts the efficacy of monoclonal antibodies targeting PD-L1 in aged tumor-bearing mice by enhancing fatty acid oxidation in CD8 T cells. These results open new therapeutic avenues to improve the effectiveness of anticancer immunotherapies in aged patients.

Keywords

• Aging
• autophagy
• immune checkpoints
• mitochondria