Zanco Journal of Pure and Applied Sciences (Oct 2024)

The Anti-Candidal Activity of Salvia verticillata subsp. verticillata Against Several Candida Species

  • Mahdi Hashim Ibrahim,
  • Badr Qader Surchi,
  • Safiya A. Azeez,
  • M. Hakkı Alma,
  • Ekrem Kireçci,
  • Mustafa A Yılmaz,
  • Metin Tansu Uguz,
  • Tufan Salan,
  • Huseyin Hüseyin Tanış

DOI
https://doi.org/10.21271/ZJPAS.36.5.2
Journal volume & issue
Vol. 36, no. 5

Abstract

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The examination of Salvia verticillata extract encompassed an exploration of its anti-Candida properties, phytochemical composition, antioxidant activity, and the quantification of total tannins. The use of ethanol as a solvent yielded the highest extraction efficiency at 26.1%. The plant exhibited a substantial tannin content of 6.5 mg/kg, signifying a noteworthy concentration. The inhibitory zones against Candida tropicalis reached a minimum diameter of 17.6 mm, while Candida guilliermondii displayed the most significant inhibition with a zone diameter of 21.8 mm. The minor inhibitory concentration (MIC) findings for all Candida species ranged from 6.25 to 12.5 g/ml. In the case of Candida guilliermondii, the synthetic antifungal activity FLU/25 demonstrated a maximal inhibition zone measuring 39.30 mm. Additionally, the maximum antioxidant activity, recorded at 0.3 ml, reached a value of 98.65. Phytochemical screening unveiled elevated concentrations of phenols and flavonoids, with malic acid (1901.1 g/g), hesperidin (302.4 g/g), and rosmarinic acid (30619.93 g/g) all experiencing an increase in concentration. These findings provide a comprehensive understanding of the diverse bioactive components and properties associated with Salvia verticillata extract.

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